Table 2. Deregulated microRNAs in JMML.
| Gene Name | Accession # | P-value | Fold-Change |
|---|---|---|---|
| Upregulated | |||
| hsa-miR-630 | MIMAT0003299 | 0.001 | 4.83 |
| hsa-miR-3195 | MIMAT0015079 | 0.014 | 2.70 |
| hsa-miR-575 | MIMAT0003240 | 0.014 | 2.69 |
| hsa-miR-4508 | MIMAT0019045 | 0.016 | 2.58 |
| hsa-miR-224-5p | MIMAT0000281 | 0.024 | 2.34 |
| hsa-miR-320e | MIMAT0015072 | 0.007 | 2.26 |
| hsa-miR-494 | MIMAT0002816 | 0.023 | 2.03 |
| hsa-miR-548ai | MIMAT0018989 | 0.009 | 1.99 |
| hsa-miR-222-3p | MIMAT0000279 | 0.018 | 1.69 |
| hsa-miR-23a-3p | MIMAT0000078 | 0.040 | 1.61 |
| hsa-miR-338-3p | MIMAT0000763 | 0.042 | 1.57 |
| Downregulated | |||
| hsa-miR-150-5p | MIMAT0000451 | 0.001 | −5.21 |
| hsa-let-7g-5p | MIMAT0000414 | 0.002 | −3.16 |
| hsa-miR-1260a | MIMAT0005911 | 0.009 | −3.01 |
| hsa-let-7a-5p | MIMAT0000062 | 0.010 | −2.98 |
| hsa-miR-4454 | MIMAT0018976 | 0.021 | −2.64 |
| hsa-miR-148a-3p | MIMAT0000243 | 0.030 | −2.31 |
| hsa-miR-146b-5p | MIMAT0002809 | 0.009 | −2.12 |
| hsa-miR-342-3p | MIMAT0000753 | 0.010 | −2.11 |
| hsa-let-7f-5p | MIMAT0000067 | 0.021 | −2.03 |
| hsa-miR-26a-5p | MIMAT0000082 | 0.034 | −2.01 |
| hsa-let-7d-5p | MIMAT0000065 | 0.038 | −2.01 |
| hsa-miR-30b-5p | MIMAT0000420 | 0.019 | −1.96 |
| hsa-miR-29b-3p | MIMAT0000100 | 0.044 | −1.94 |
| hsa-miR-29a-3p | MIMAT0000086 | 0.024 | −1.70 |
Significant deregulated microRNAs in JMML patients compared to Healthy Donors controls (P<0.05; see miR expression data analysis paragraph in Matherials and Methods section). Accession numbers from miRBase (http://www.mirbase.org) are reported for each miRNA.