Table 2. Meta-analysis of associations between the rs4245739 polymorphism and cancer risk.

Comparison	Overall and Stratification analyses	Studies	OR (95% CI)	P-value	Random/Fixed effect model	P for heterogeneity	I2 (%)
C vs. A	Overall	51	0.78(0.68,0.89)	<0.001	Random	<0.001	90.6
	Caucasian	44	1.02(0.92,1.12)	0.301	Random	<0.001	88.5
	Asian	7	0.53 (0.45,0.62)	<0.001	Random	0.584	0.0
	Gastrointestinal cancer	3	0.74(0.49,1.12)	0.157	Random	0.001	85.6
	Lung cancer	3	0.61(0.31,1.19)	0.148	Random	<0.001	90.4
	Breast cancer	43	0.78 (0.59,1.02)	0.070	Random	<0.001	94.4
	Other cancers	2	0.70(0.35,1.39)	0.307	Random	0.024	80.5
CC vs. AA+AC	Overall	47	1.04(0.88,1.21)	0.666	Random	0.016	59.5
	Caucasian	44	1.03 (0.86,1.23)	0.748	Random	0.584	0.0
	Asian	3	1.20(0.38,3.84)	0.754	Random	0.032	78.1
	Gastrointestinal cancer	3	1.00 (0.80,1.26)	0.996	Random	0.895	0.0
	Lung cancer	2	1.07(0.85,1.36)	0.556	Random	0.953	0.0
	Breast cancer	41	1.08(0.75,1.55)	0.696	Random	0.003	88.4
	Other cancers	1	0.90 (0.74,1.10)	0.312	Na	Na	Na
CC+AC vs. AA	Overall	51	0.75(0.64,0.87)	<0.001	Random	<0.001	90.1
	Caucasian	44	1.02(0.91,1.14)	0.740	Random	<0.001	85.5
	Asian	7	0.51(0.43,0.60)	<0.001	Random	0.662	0.0
	Gastrointestinal cancer	3	0.72 (0.45,1.14)	0.157	Random	<0.001	87.0
	Lung cancer	3	0.59(0.29,1.20)	0.142	Random	<0.001	90.5
	Breast cancer	43	0.76(0.56,1.04)	0.089	Random	<0.001	94.0
	Other cancers	2	0.69 (0.34,1.39)	0.294	Random	0.025	80.0
	Male	5	0.72 (0.49,1.07)	0.107	Random	0.008	70.8
	Female	5	0.62 (0.32,1.19)	0.150	Random	<0.001	83.4
	Smoker	4	0.83 (0.61,1.13)	0.237	Fixed	0.413	0.0
	Nonsmoker	4	0.44 (0.31,0.63)	<0.001	Fixed	0.480	0.0
CC vs. AA	Overall	47	1.04(0.85,1.26)	0.360	Random	0.001	71.8
	Caucasian	44	1.03(0.83,1.28)	0.769	Random	<0.001	83.8
	Asian	3	1.13 (0.35,3.59)	0.840	Random	0.938	0.0
	Gastrointestinal cancer	3	1.01(0.80,1.28)	0.915	Random	<0.001	90.6
	Lung cancer	2	1.08(0.85,1.38)	0.522	Random	<0.001	88.5
	Breast cancer	41	1.09 (0.70,1.71)	0.698	Random	0.584	0.0
	Other cancers	1	0.88(0.71,1.08)	0.208	Random	0.032	78.1
AC vs. AA	Overall	51	0.75 (0.64,0.87)	<0.001	Random	<0.001	88.6
	Caucasian	44	1.02 (0.93,1.12)	0.694	Random	0.001	77.3
	Asian	7	0.51(0.43,0.60)	<0.001	Random	0.747	0.0
	Gastrointestinal cancer	3	0.70(0.43,1.14)	0.157	Random	<0.001	87.7
	Lung cancer	3	0.58(0.29,1.19)	0.136	Random	<0.001	90.0
	Breast cancer	43	0.78(0.58,1.04)	0.091	Random	<0.001	92.6
	Other cancers	2	0.70(0.35,1.39)	0.307	Random	0.028	79.3

*Bold values are statistically significant (P < 0.05). OR, odds ratio; 95% CI, 95% confidence interval; Na, not available.