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| Adverse events | Grade 1/2 | Grade3/4 | ||
|---|---|---|---|---|
| No. | % | No. | % | |
| Hematologic | ||||
| Leukopenia | 9 | 37.50 | 14 | 58.33 |
| Neutropenia | 5 | 20.83 | 18 | 75.00 |
| Anemia | 14 | 58.33 | 9 | 37.50 |
| Thrombocytopenia | 6 | 25.00 | 11 | 45.83 |
| Nonhematologic | ||||
| Nausea/vomiting | 14 | 58.33 | 7 | 29.17 |
| ALT/AST elevation | 14 | 58.33 | 1 | 4.17 |
| Increased BUN | 2 | 8.33 | 0 | -- |
| Heighten of hemodiastase | 0 | |||
| Increased urinary amylase | 0 | |||
| Coagulation disorders | ||||
| APTT elongation | 12 (50.00%) | |||
| Hypofibrinogenemia | 14 (58.33%) | |||
