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. 2016 Jun 14;7(34):55811–55827. doi: 10.18632/oncotarget.10046

Figure 2. Bioactivation of inorganic sulfate.

Figure 2

Inorganic sulfate is converted to the biologically active form PAPS (3′-phosphoadenosine 5′-phosphosulfate) by the dual-function enzyme PAPSS. Inorganic sulfate is first converted to adenosine 5′-phosphosulfate (APS) by ATP sulfurylase. The intermediate molecule APS is subsequently phosphorylated via the APS kinase domain of PAPSS to form PAPS. The structures were drawn using ChemSketch and are color-coded as follows: red = oxygen, cyan = carbon, blue = nitrogen, yellow = sulfur, grey = phosphorous.