Figure 5. The inhibitory effect of MEK-162 on murine corticotroph tumors in vivo.
Athymic nude mice were inoculated subcutaneously with corticotroph tumor AtT20 cells (5 × 105 cells per mouse in 0.1 mL matrigel). Three days after tumor cell injection, mice were randomly divided into three groups to receive either vehicle or MEK-162 at 3.5 mg· kg−1 or 10 mg ·kg−1 administered p.o. twice a day for 22 days. Graphic depiction of tumor growth rates A., tumor weights B., and circulating ACTH levels C. and corticosterone levels D. measured in the MEK-treated groups compared to vehicle-treated tumor bearing mice. Values are mean ± standard error, *p < 0.05,**p < 0.01.