Table 1. Frequency of TERT promoter and CTNNB1 mutations in hepatocellular nodules.
TERT C228T & C250T status | CTNNB1 status | ||||
---|---|---|---|---|---|
Total | Wild type | Mutant | Wild type | Mutant | |
(n = 156) | (n = 107) | (n = 45) | (n = 127) | (n = 17) | |
Hepatic adenoma | 9 | 9 (100%) | 0 | 8 (88.9%) | 1 (11.1%) |
Regenerating nodule | 4 | 4 (100%) | 0 | 2 (100%) | 0 |
Low grade dysplastic nodule (Large cell change) | 10 | 10 (100%) | 0 | 8 (100%) | 0 |
High grade dysplastic nodule | 7 | 7(100%) | 0 | 6 (100%) | 0 |
Hepatocellular carcinoma | 123 | 74 (60.2%) | 45 (36.6%) | 100 (86.2%) | 16 (13.8%) |
Combined hepatocellular carcinoma and cholangiocarcinoma | 3 | 3 (100%) | 0 | 3 (100%) | 0 |