Figure 6. Stimulation of intracellular calcium mobilization in RBL-2H3 cells by MRS 2690 (1.0 μM; 10.0 μM; 100.0 μM) and the effect of TMPS pre-treatment (10.0 μM; 100.0 μM; 1000.0 μM).
A. Time course of mean Ca2+ responses (Fluo-8 ratio) after MRS 2690 application; B. The maximal fluorescence intensity obtained from traces shown in A; C. The influence of TMPS pre-treatment on MRS 2690-induced (10.0 μM) calcium mobilization; D. The influence of TMPS pre-treatment on MRS 2690-induced (100.0 μM) calcium mobilization; E. the maximal fluorescence intensity obtained from traces shown in C and D. Data represent the means ± SD from at least three independent experiments; * p < 0.05, ** p < 0.01 *** p < 0.001 when compared to MRS 2690.