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. 2016 Sep 2;7(43):69565–69578. doi: 10.18632/oncotarget.11829

Figure 1. uPAR (Plaur) overexpression in rat asbestos-induced malignant mesothelioma (MM) and rat/human MM cell lines in association with prognosis.

Figure 1

Microarray uPAR expression for (A) histological subtype and (B) asbestos fiber. (C) uPAR expression in rat MM tissues with quantitative RT-PCR and Western blot analysis. (D) uPAR immunostaining in rat tissue array with spleen/lung/liver (rat normal tissues from left to right) surface lining mesothelial cells as control (arrow, bar = 50 μm). (E) Strong uPAR expression in rat MM was associated with poorer survival. (F, G) uPAR expression in rat and human MM cell lines with quantitative RT-PCR and Western blot analysis. MM, malignant mesothelioma; EM, epithelioid subtype mesothelioma; SM, sarcomatoid subtype mesothelioma; BM, biphasic subtype mesothelioma; ND, mesothelioma of not determined subtype (means ± SEM; representative of three independent assays; *P < 0.05, **P < 0.01). See text for details.