Table 3. The association of clinical factors and the miRNA signature risk score with OS in PC patients.
| Variables | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | |
| Gender (female VS. male) | 0.799 (0.469, 1.363) | 0.411 | ||
| Age (≥ 65 VS. < 65) | 1.523 (0.899, 2.578) | 0.118 | ||
| Location (tail VS. body VS. head) | 0.586 (0.338, 1.016) | 0.057 | ||
| Size (≥ 35 VS. < 35; mm) | 1.843 (1.063, 3.192) | 0.029 | 0.824 (0.427, 1.588) | 0.562 |
| Grade (G4 vs. G3 VS. G2 VS. G1) | 1.763 (1.247, 2.492) | 0.001 | 1.712 (1.141, 2.568) | 0.009 |
| Residual tumor (yes Vs. no) | 2.254 (1.294, 3.927) | 0.004 | 1.627 (0.82, 3.225) | 0.164 |
| TNM stage (IV VS. III VS. IIB VS. IIA VS. IB VS. IA) | 1.723 (1.231, 2.41) | 0.002 | 1.459 (0.939,2.267) | 0.093 |
| Smoking (smoker VS. non-smoker) | 1.13 (0.662, 1.932) | 0.654 | ||
| Drinking (drinker VS. none-drinker) | 0.76 (0.358, 1.614) | 0.476 | ||
| Diabetes (yes VS. no) | 0.909 (0.467, 1.767) | 0.778 | ||
| Adjuvant radiotherapy (yes VS. no) | 0.337 (0.152, 0.746) | 0.007 | 0.653 (0.24, 1.773) | 0.403 |
| MTT (yes VS. no) | 0.453 (0.265, 0.774) | 0.004 | 0.256 (0.117, 0.562) | 0.001 |
| Treatment outcome (SD + PD VS. CR + PR) | 2.25 (1.222, 4.145) | 0.009 | 1.427 (0.733, 2.779) | 0.296 |
| Risk score (high VS. low) | 3.196 (1.795, 5.689) | < 0.001 | 2.641 (1.194, 5.845) | 0.017 |
HR: hazard ratio; CI: confidence interval; SD: stable disease; PD: progressive disease; CR: complete response; PR: partial response.