Table 3. Histological and immunohistochemical characteristics of lymphoepithelioma-like cholangiocarcinoma.
| Case | LELC Component | GCWLI | GCWOLI | HepPar−1 | CK7 | CK19 | PD−L1 | EBER | |
|---|---|---|---|---|---|---|---|---|---|
| Tumor cells | Immune cells | ||||||||
| 1 | 60% | 40% | 0 | − | + | + | − | + (2) | + |
| 2 | 80% | 20% | 0 | − | + | + | + (3) | + (2) | + |
| 3 | 90% | 10% | 0 | − | + | + | + (3) | + (1) | − |
| 4 | > 90% | < 10% | 0 | − | + | + | − | + (3) | + |
| 5 | > 90% | < 10% | 0 | − | + | + | + (3) | + (2) | − |
| 6 | 80% | 0 | 20% | − | + | + | + (3) | + (2) | − |
| 7 | 40% | 60% | 0 | − | + | + | − | + (3) | + |
| 8 | 90% | 10% | 0 | − | + | + | + (1) | + (2) | − |
| 9 | 60% | 40% | 0 | − | + | + | + (1) | + (1) | + |
| 10 | 70% | 30% | 0 | − | + | + | + (1) | + (2) | − |
| 11 | 90% | 10% | 0 | − | + | + | + (1) | + (1) | + |
| 12 | 60% | 40% | 0 | − | + | + | + (1) | + (2) | + |
| 13 | 80% | 20% | 0 | − | + | + | + (2) | + (2) | + |
LELC, lymphoepithelioma-like carcinoma.
GCWLI, Glandular component with lymphocytic infiltration.
GCWOLI, Glandular component without lymphocytic infiltration.
The negative cases ‘−’ < 5% positive.
The intensity of PD-L1 expression was scored as follows: 1, weak; 2, moderate; and 3, strong staining in more than 5% of cells.