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. 2016 Sep 10;7(43):69760–69769. doi: 10.18632/oncotarget.11951

Figure 1. Ibrutinib irreversible binding mode exploration.

Figure 1

(A) Ibrutinib and WZ4002 anti-proliferation effects against the H1975 cell line by removal of drug after 1 h, 4 h and 72 h treatment. (B) Ibrutinib and WZ4002 inhibitory effects on EGFRY1068 auto-phosphorylation in the H1975 cell line at different time points by removal of drug after 4 h pretreatment. (C) Ibrutinib and WZ4002 anti-proliferation effects against the HCC827 cell line by removal of drug after 1 h, 4 h and 72 h treatment. (D) Ibrutinib and WZ4002 inhibitory effects on EGFRY1068 auto-phosphorylation in the HCC827 cell line at different time points by removal of drug after 4 h pretreatment. (E) Micro-Scale Thermophoresis (MST) technology based binding Kd test of Ibrutinib and WZ4002 against EGFR T790M/L858R kinase.