Table 1. Association between epithelial HIF-1α expression and clinicopathological phenotype and hormone receptor status in endometrial cancer patients.
| Variable | Categories | Epithelial HIF-1α protein expression | ||
|---|---|---|---|---|
| Low % (N) | High % (N) | P* | ||
| Histological type & grade | EEC Grade 1–2 | 76 (373) | 24 (119) | 0.03 |
| N = 735 | EEC Grade 3 | 82 (88) | 18 (20) | |
| NEEC | 86 (116) | 14 (19) | ||
| Myometrial infiltration | < 50% | 75 (339) | 25 (114) | 0.002 |
| N =732 | > 50% | 85 (236) | 15 (43) | |
| Lymph node metastasis | No | 76 (406) | 24 (126) | 0.004 |
| N=596 | Yes | 92 (59) | 8 (5) | |
| FIGO stage (2009) | I/II | 76 (473) | 24 (147) | 0.001 |
| N = 735 | III/IV | 90 (104) | 10 (11) | |
| ERα protein expression | High | 76 (412) | 24 (128) | 0.01 |
| N = 727 | Low | 85 (159) | 15 (28) | |
| PR protein expression | High | 76 (426) | 24 (133) | 0.005 |
| N = 727 | Low | 86 (145) | 14 (23) | |
Abbreviations: HIF, hypoxia-inducible factor; EEC, endometrioid endometrial cancer; NEEC, non-endometrioid endometrial cancer; ER, estrogen receptor; PR; progesterone receptor; N, number of patients assessed for epithelial HIF-1α protein expression.
*
Chi-square test.