Table 3. Prognostic value of epithelial and stromal protein expression of HIF-1α in relation to established prognostic factors in endometrial cancer.
| Variable | N (%) | Unadjusteda | Adjusted | ||||
|---|---|---|---|---|---|---|---|
| HR | 95% CI | P* | HR | 95% CI | P* | ||
| Age at treatment (mean=64.1) | 557 | 1.1 | 1.0–1.1 | < 0.001 | 1.0 | 1.0–1.1 | 0.009 |
| Histological type & grade | |||||||
| Endometrioid Grade 1–2 | 383 (68.8) | 1 | 1 | ||||
| Endometrioid Grade 3 | 79 (14.2) | 6.6 | 3.1–13.6 | < 0.001 | 4.8 | 2.2–10.0 | < 0.001 |
| Non-Endometrioid | 95 (17.1) | 16.0 | 8.3–30.9 | < 0.001 | 10.8 | 5.4–21.9 | < 0.001 |
| Myometrial invasion | < 0.001 | 0.006 | |||||
| < 50% | 351 (63.0) | 1 | 1 | ||||
| > 50% | 206 (37.0) | 3.8 | 2.3–6.4 | 2.3 | 1.3–4.1 | ||
| Lymph node metastasis | < 0.001 | < 0.001 | |||||
| No | 503 (90.3) | 1 | 1 | ||||
| Yes | 54 (9.7) | 8.0 | 4.8–13.3 | 3.0 | 1.7–5.4 | ||
| Epithelial HIF-1α | 0.03 | 0.970 | |||||
| Low | 434 (77.9) | 2.5 | 1.1–5.6 | 1 | 0.4–2.5 | ||
| High | 123 (22.1) | 1 | 1.0 | ||||
| Stromal HIF-1α | 0.004 | 0.04 | |||||
| Low | 391 (70.2) | 1 | 1 | ||||
| High | 166 (29.8) | 2.1 | 1.3–3.4 | 1.7 | 1.0–2.9 | ||
HIF, hypoxia-inducible factor; CI, confidence interval; HR, hazard ratio; N, number of cases.
a
Unadjusted (univariate) analysis conducted in 557 patients with data available for all variables in the adjusted (multivariate; including all listed variables) analysis.
*
Cox proportional hazard model.