Table 4. Tumor HIF-1α protein expression pattern in relation to preoperative functional MRI and metabolic FDG-PET/CT parameters of endometrial cancer lesions.
| Imaging parameter | Epithelial HIF-1α | Stromal HIF-1α | ||||
|---|---|---|---|---|---|---|
| Low Mean (N) | High Mean (N) | P* | High Mean (N) | Low Mean (N) | P* | |
| MRI | ||||||
| Fb (ml/100 ml/min) | 49.7 (124) | 48.0 (37) | 0.99 | 47.5 (48) | 50.6 (109) | 0.67 |
| Ktrans (/min) | 0.037 (122) | 0.034 (37) | 0.64 | 0.038 (48) | 0.035 (107) | 0.27 |
| kep (/min) | 0.42 (122) | 0.44 (36) | 0.29 | 0.44 (48) | 0.42 (106) | 0.22 |
| Ve (ml/100 ml) | 11.4 (122) | 9.1 (36) | 0.23 | 11.7 (48) | 10.4 (106) | 0.59 |
| IAUGC (mMs) | 69 (124) | 68 (37) | 0.81 | 69 (48) | 69 (109) | 0.80 |
| ADC (× 10−6 m2/s) | 800 (123) | 789 (36) | 0.50 | 787 (48) | 802 (107) | 0.64 |
| Volume (ml) | 22 (124) | 15 (37) | 0.48 | 30 (48) | 16 (109) | 0.21 |
| FDG PET-CT | ||||||
| SUVmax (g/ml) | 14.8 (75) | 14.1 (27) | 0.79 | 16.0 (29) | 14.0 (71) | 0.17 |
| SUVmean (g/ml) | 5.9 (75) | 5.8 (26) | 0.76 | 6.5 (28) | 5.6 (71) | 0.06 |
| MTV (ml) | 33 (77) | 24 (29) | 0.13 | 45 (30) | 25 (74) | 0.09 |
| TLG (g) | 235 (75) | 169 (26) | 0.43 | 336 (28) | 173 (71) | 0.02 |
Abbreviations: HIF, hypoxia-inducible factor; MRI, magnetic resonance imaging; FDG-PET/CT, fluorodeoxyglucose positron emission tomography/computed tomography; N, number of cases; Fb, blood flow; Ktrans, transfer from blood to EES; kep, transfer constant from blood extravascular extracellular space (EES) to blood; Ve, fractional volume of EES; IAUGC, integrated area under the concentration time curve; ADC, apparent diffusion coefficient; SUVmax, maximum standard uptake value; SUVmean, mean standard uptake value; MTV, metabolic tumor volume; TLG, total lesion glycolysis.
*
Mann-Whitney U-test.