Table 1. Inhibitory effects of Bisindolylmaleimide IX on a variety of kinases.
enzyme compounds | IC50 | |||||||
---|---|---|---|---|---|---|---|---|
Aurora A | B-Raf | IKKβ | Jak2 | SYK | BCR-ABL | ERK1 | MEK1 | |
Bis-IX (μM) | >45 | 1.14±0.11 | 0.48±0.005 | 9.68±0.79 | > 45 | > 45 | > 45 | > 45 |
Stauprorine (nM) | 13.71±2.71 | 3.37±0.17 | 1.54±0.12 | 0.76±0.04 | 1.16±0.08 | N.D. | N.D. | N.D. |
Imatinib (μg/ml) | N.D. | N.D. | N.D. | N.D. | N.D. | 0.023±0.003 | N.D. | N.D. |
N.D. : not determined