Table 2. Multivariate analysis of the risk factors for OS and RFS.
| Variable▲ | Recurrence-Free Survival | Overall Survival | ||
|---|---|---|---|---|
| Hazard ratio (95% CI) | p-value | Hazard ratio (95% CI) | p-value | |
| Gender, Female | -- | -- | 0.446 (0.225-0.885) | 0.021★ |
| Hepatocirrhosis, Present | 1.414 (1.040-1.922) | 0.027★ | -- | -- |
| Edmondson grade, III + IV | -- | -- | 0.845 (0.519-1.377) | 0.500 |
| Tumor size (cm), ≥ 5 | -- | -- | 1.671 (1.166-2.395) | 0.005★ |
| Satellite lesions, Present | 1.478 (0.865-2.525) | 0.153 | -- | -- |
| TNM stage, II−IV | 1.644 (1.145-2.361) | 0.007★ | 1.934 (1.327-2.819) | 0.001★ |
| Serum AFP (ug/L), ≥ 20 | 1.274 (0.941-1.726) | 0.117 | 1.689 (1.152-2.476) | 0.007★ |
| PON3 expression, Low | 1.379 (1.021-1.863) | 0.036★ | 1.687 (1.173-2.426) | 0.005★ |
▲
Variables were adopted for their prognostic significance by univariate analysis.
★
p < 0.05 by Cox proportional hazards regression model.