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. 2016 Sep 21;7(43):70143–70151. doi: 10.18632/oncotarget.12160

Figure 3. Ectopic ISG15 and USP18 induces cancer cell apoptosis.

Figure 3

(A) Blood cancer cells were stably infected with lentiviral ISG15 or mock lentivirus. Cell lysates were harvested at 96 hrs after infection to measure PARP and Caspase-3 cleavage by immunoblotting assay. (B) HeLa cells were transfected with ISG15 or USP18 plasmids for 48 or 60 hrs before being collected for immunoblotting against PARP and Caspase-3. (C) HeLa cells were transfected with ISG15 and USP18 plasmids, respectively. Cell proliferation was analyzed on a microscope and the cell images were photographed at 48 hrs after transfection.