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. 2016 Sep 15;7(43):70524–70534. doi: 10.18632/oncotarget.12045

Figure 3. Characterization of miRNA expression.

Figure 3

A. Among 31 microRNAs upregulated by more than 4-fold in primary tumors, 27 were also significantly upregulated in recurrent tumor samples. B. Likewise, among 35 microRNAs downregulated by more than 4-fold in primary tumors, 34 were also significantly downregulated in recurrent tumor samples. C. Expression profiles of miRNAs in primary ovarian HGSC compared with those of normal ovarian tissue were similar to those in recurrent ovarian HGSC compared with normal ovarian tissue (correlation coefficient = 0.811, P = 0.0078). D. Primary and recurrent ovarian HGSC samples were not separated in three-dimensional principal components analysis, although normal ovarian specimens clustered together.