Table 1. Clinical and Molecular data of Cancers.

	BRAF mutant/MSI	BRAF mutant/MSS	BRAF wild type /MSS	p value	P ValueA	P ValueB	P ValueC
RBWH cancers:
n	54	33	79	-	-	-	-
Average age (yrs)	74.6	68.4	68.2	0.005	0.026	0.003	0.900
Female gender	42/54 (77.8%)	17/33 (51.5%)	33/79 (18.4%)	0.0002	0.017	<0.0001	0.407
Proximal site	41/43 (95.3%)	17/24 (70.8%)	15/63 (23.8%)	<0.0001	0.008	<0.0001	0.0001
CIMP high	54/54 (100%)	32/33 (96.7%)	12/79 (15.1%)	<0.0001	0.379	<0.0001	<0.0001
Envoi cancers:
n	63	37	44	-	-	-	-
Average age (yrs)	77.9	72.6	63.6	<0.0001	0.01	<0.0001	0.004
Female gender	37/57 (64.9%)	26/37 (70.2%)	13/28 (46.4%)	0.12	0.66	0.16	0.07
Proximal site	53/57 (93.0%)	30/37 (81.1%)	9/28 (32.1%)	<0.0001	0.10	<0.0001	<0.0001
CIMP high	59/63 (93.7%)	23/35 (65.7%)	0/35 (0%)	<0.0001	0.001	<0.0001	<0.0001

^AP Value: P value between BRAF mutant/MSI and BRAF mutant/MSS cohorts;

^BP Value: P value between BRAF mutant/MSI and BRAF wild type cohorts;

^CP Value: P value between BRAF mutant/MSS and BRAF wild type cohorts