Table 3. Frequency and type of ZNRF3 mutations.
Cohort | n | Number of cancers mutated | Total number of mutations | Frameshift mutations | Mis/nonsense (%A) (%B) |
---|---|---|---|---|---|
BRAF mutant /MSI | 54 | 16 (29.6%) | 18 | 13 (24.1%) | 5 (9.3%) |
BRAF mutant /MSS | 33 | 5 (15.2%) | 5 | 1 (3.0%) | 4 (9.1%) |
BRAF wild type /MSS | 27 | 0 | 0 | 0 | 0 |
P value for number of mutations: Overall p=0.004; BRAF mutant/MSI vs BRAF mutant/MSS p=0.2; BRAF mutant/MSI vs BRAF wild type p=0.008; BRAF mutant/MSS vs BRAF wild type p=0.06