Figure 1. Intra-tumour activation of the PTEN/Akt pathway is associated with cancer-specific survival in CRC patients.

A. Kaplan Meier curve showing that in 201 CRC patients, cPTEN does not associate with CSS. B. Kaplan Meier curve showing that in 201 CRC patients, phosphorylation of mAkt⁴⁷³ does not associate with CSS. C. Kaplan Meier curves show that in 201 CRC patients, the simple model shows a slight trend towards poorer CSS. D. Whereas when cPTEN and mAkt⁴⁷³ were combined using the off/on model, there is a significant association with poorer CSS.