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. 2016 Sep 20;7(43):70601–70612. doi: 10.18632/oncotarget.12134

Table 1. PTEN/Akt473/COX-2 expression and survival in patients undergoing elective, potentially curative resection of colorectal cancer (n=201).

N (%) 10yr-CSS %
(SEa)		 Univariate HRb
(95% CIc)		 P
Cytoplasmic Akt473
 Low expression
 High expression 		95 (47)
106 (53)		 70 (5)
65 (5)		 1.15 (0.70-1.89) 0.592
Membrane Akt473
 Low expression
 High expression 		160 (80)
41 (20)		 70 (4)
56 (9)		 1.36 (0.76-2.45) 0.296
Cytoplasmic PTEN
 Low expression
 High expression 		102 (51)
109 (49)		 67 (5)
69 (5)		 0.96 (0.58-1.58) 0.862
Membrane PTEN
 Low expression
 High expression 		123 (61)
78 (39)		 65 (5)
72 (6)		 0.71 (0.41-1.20) 0.194
Combined cPTEN/mAkt473 (simple model)
 High PTEN/Low Akt473
 High PTEN/High Akt473
 Low PTEN/Low Akt473
 Low PTEN/High Akt473 		77 (38)
83 (41)
22 (11)
19 (10)		 69 (6)
71 (5)
60 (17)
47 (11)		 1.14 (0.88-1.48) 0.159
Combined cPTEN/mAkt473 (off/on model)
 All others (OFF)
 Low PTEN/High Akt473 (ON) 		182 (90)
19 (10)		 70 (4)
47 (11)		 2.06 (1.05-4.07) 0.032
cPTEN/mAkt473 off/on model (No nuclear COX-2; n=158)
 All others (OFF)
 Low PTEN/High Akt473 (ON) 		142 (90)
15 (10)		 69 (4)
33 (12)		 3.04 (1.51-6.10) 0.001
cPTEN/mAkt473 off/on model (with nuclear COX-2; n=45)
 All others (OFF)
 Low PTEN/High Akt473 (ON) 		40 (91)
4 (9)		 72 (7)
100 (0)		 0.42 (0.00-185.51) 0.251
a

SE= Standard Error,

b

HR= Hazard Ratio,

c

CI= Confidence Interval.