Table 2. Relationship between cPTEN/mAkt473/nCOX-2 expression, clinicopathological characteristics and inflammatory responses in patients undergoing elective, potentially curative resection of colorectal cancer (n=201).
| cPTEN/mAkt473 | Absent nCOX-2 cPTEN/mAkt473 |
|||||
|---|---|---|---|---|---|---|
| OFF (n=182) |
ON (n=19) |
P | OFF (n=142) |
ON (n=15) |
P | |
| Clinicopathological Characteristics | ||||||
|
Age <65 >65 |
73 (40) 109 (60) |
8 (42) 11 (58) |
0.866 | 50 (35) 92 (65) |
7 (47) 8 (53) |
0.380 |
|
Sex Female Male |
87 (48) 95 (52) |
9 (47) 10 (53) |
0.971 | 67 (47) 75 (53) |
7 (47) 8 (53) |
0.970 |
|
Adjuvant No Yes |
132 (73) 50 (27) |
13 (68) 6 (32) |
0.704 | 105 (74) 37 (26) |
10 (67) 5 (33) |
0.545 |
|
Tumour site Colon Rectum |
121 (66) 61 (34) |
12 (63) 7 (37) |
0.771 | 90 (63) 52 (37) |
10 (67) 5 (33) |
0.801 |
|
T stage 1 2 3 4 |
8 (4) 14 (8) 119 (65) 41 (23) |
0 (0) 1 (6) 9 (47) 9 (47) |
0.030 | 6 (4) 13 (10) 93 (65) 30 (21) |
0 (0) 1 (7) 6 (40) 8 (53) |
0.022 |
|
N stage 1 2 3 |
103 (56) 63 (35) 16 (9) |
7 (37) 10 (53) 2 (10) |
0.174 | 80 (56) 51 (36) 11 (8) |
5 (33) 8 (54) 2 (13) |
0.103 |
|
Differentiation Mod/well Poor |
164 (90) 18 (10) |
14 (74) 5 (26) |
0.032 | 131 (93) 11 (7) |
11 (73) 4 (27) |
0.018 |
|
Venous invasion Absent Present |
123 (68) 59 (32) |
7 (37) 12 (63) |
0.008 | 94 (66) 48 (34) |
4 (27) 11 (73) |
0.003 |
|
Margin involvement No Yes |
176 (97) 6 (3) |
18 (95) 1 (5) |
0.656 | 136 (96) 6 (4) |
14 (94) 1 (6) |
0.663 |
|
Peritoneal involvement No Yes |
141 (77) 41 (23) |
9 (47) 10 (53) |
0.004 | 112 (79) 30 (21) |
6 (40) 9 (60) |
0.001 |
|
Mismatch repair status Competent Deficient |
158 (87) 24 (13) |
16 (84) 3 (16) |
0.759 | 126 (89) 16 (11) |
13 (87) 2 (13) |
0.819 |
|
Proliferation Index Low High |
67 (37) 115 (63) |
5 (26) 14 (74) |
0.362 | 51 (36) 91 (64) |
5 (33) 10 (67) |
0.855 |
|
Necrosis Low High |
113 (62) 69 (38) |
9 (47) 10 (53) |
0.214 | 91 (64) 51 (36) |
7 (47) 8 (53) |
0.187 |
|
Tumour stroma percentage (n=182) Low High |
130 (78) 36 (22) |
10 (63) 6 (37) |
0.152 | 105 (81) 24 (19) |
8 (62) 5 (38) |
0.091 |
|
Tumour Budding (n=186) No Yes |
117 (69) 53 (31) |
9 (56) 7 (44) |
0.304 | 90 (68) 42 (32) |
6 (46) 7 (54) |
0.109 |
| Inflammatory Characteristics | ||||||
|
Klintrup-Makinen grade Strong Weak |
65 (36) 117 (64) |
7 (37) 12 (63) |
0.936 | 51 (36) 90 (64) |
6 (40) 9 (60) |
0.770 |
|
mGPS 0 1 2 |
104 (57) 55 (30) 23 (13) |
14 (74) 5 (26) 0 (0) |
0.081 |
83 (58) 44 (31) 15 (11) |
11 (73) 4 (27) 0 (0) |
0.160 |
|
NPS (n=114) 0 1 2 |
67 (68) 31 (31) 1 (1) |
11 (73) 3 (20) 1 (7) |
0.224 | 59 (70) 24 (29) 1 (1) |
9 (69) 3 (23) 1 (8) |
0.296 |
|
NLR (n=177) ≤ 5 > 5 |
124 (78) 35 (22) |
15 (83) 3 (17) |
0.601 | 106 (84) 20 (16) |
12 (86) 2 (14) |
0.877 |