Table 3. Combination index values for the effect of Ibrutinib/Nutlin-3 combination on viability of leukemic B-cell lines.

Leukemic cells	ED50	ED75	ED90	Average CI
EHEB	0.80	0.60	0.48	0.63
JVM-2	0.52	0.50	0.50	0.51
JVM-3	0.49	0.19	0.07	0.25
MEC-1	0.42	0.61	0.88	0.64
MEC-2	0.45	0.54	0.67	0.83

ED indicates effect dose. The average combination index (CI) values were calculated from ED50, ED75 and ED90.