Table 4. Combination index values for the effect of Ibrutinib/Nutlin-3 combination on viability of B-CLL patient cells.

Leukemic cells	ED50	ED75	ED90	Average CI
Patient #1	0.91	0.67	0.50	0.69
Patient #2	0.50	0.54	0.58	0.54
Patient #3	1.02	0.39	0.30	0.57
Patient #7	0.37	0.20	0.11	0.23
Patient #9	1.19	1.43	1.76	1.46
Patient #10	0.34	0.21	0.13	0.23
Patient #11	0.74	0.37	0.19	0.43
Patient #12	0.28	0.20	0.18	0.22
Patient #14	0.16	0.08	0.04	0.09
Patient #15	0.52	0.21	0.10	0.28
Patient #16	0.56	0.33	0.20	0.36

ED indicates effect dose. The average combination index (CI) values were calculated from ED50, ED75 and ED90.