Table 2. Multivariate Cox regression analyses in the training and validation cohort.
| Variables | TTR | OS | ||
|---|---|---|---|---|
| HR(95% CI) | P | HR(95% CI) | P | |
| Training cohort | ||||
| AFP, ng/ml (>400 vs ≤400) | 1.048 (0.681-1.641) | 0.832 | 0.548 (0.282-1.068) | 0.077 |
| γ-GT, U/L (>54 vs ≤54) | 2.488 (1.654-3.743) | <0.001 | 1.930 (1.117-3.332) | 0.018 |
| No. of tumors, (multiple vs single) | 0.856 (0.508-1.443) | 0.559 | 1.065 (0.547-2.076) | 0.852 |
| Tumor size, cm (>5 vs ≤5) | 0.861 (0.553-1.340) | 0.507 | 1.483 (0.838-2.625) | 0.176 |
| Tumor encapsulation, (none vs complete) | 1.250 (0.833-1.875) | 0.281 | 1.196 (0.690-2.074) | 0.524 |
| Satellite lesion, (yse vs no) | 0.907 (0.484-1.700) | 0.761 | 0.776 (0.330-1.827) | 0.562 |
| Vascular invasion, (yes vs no) | 0.735 (0.474-1.139) | 0.169 | 0.707 (0.392-1.275) | 0.249 |
| Tumor differentation, (III-IV VS I-II) | 1.014 (0.662-1.552) | 0.950 | 1.102 (0.623-1.950) | 0.738 |
| ApoA-1, g/L (>1.04 vs ≤1.04) | 0.394 (0.260-0.598) | <0.001 | 0.474 (0.273-0.824) | 0.008 |
| Validation cohort | ||||
| AFP, ng/ml (>400 vs ≤400) | 1.205 (0.717-2.024) | 0.481 | 1.199 (0.623-2.307) | 0.588 |
| γ-GT, U/L (>54 vs ≤54) | 1.158 (0.731-1.834) | 0.532 | 1.484 (0.821-2.685) | 0.191 |
| No. of tumors, (multiple vs single) | 1.041 (0.576-1.881) | 0.895 | 0.923 (0.427-1.994) | 0.837 |
| Tumor size, cm (>5 vs ≤5) | 1.640 (0.974-2.760) | 0.063 | 1.537 (0.796-2.969) | 0.200 |
| Tumor encapsulation, (none vs complete) | 0.782 (0.485-1.261) | 0.313 | 0.678 (0.371-1.238) | 0.206 |
| Satellite lesion, (yse vs no) | 1.183 (0.581-2.411) | 0.643 | 1.159 (0.464-2.894) | 0.751 |
| Vascular invasion, (yes vs no) | 0.971 (0.577-1.636) | 0.913 | 0.828 (0.427-1.604) | 0.575 |
| Tumor differentation, (III-IV VS I-II) | 1.204 (0.743-1.953) | 0.451 | 0.948 (0.508-1.769) | 0.867 |
| ApoA-1, g/L (>1.04 vs ≤1.04) | 0.532 (0.326-0.868) | 0.011 | 0.444 (0.243-0.772) | 0.010 |
Abbreviations: AFP, α-fetoprotein; γ-GT, γ-Glutamyltransferase; ApoA-1, Apolipoprotein A1; TTR, time to recurrence; OS, Overall survival; HR, hazard ratio; CI, confidence interval.