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. 2016 Sep 27;7(43):70857–70868. doi: 10.18632/oncotarget.12268

Figure 1. Gemcitabine treatment induces miR-145 up-regulation in gemcitabine-sensitive pancreatic adenocarcinoma cells.

Figure 1

A and B. Pancreatic adenocarcinoma cells Bxpc-3 (A) and Panc-1 (B) were treated with gemcitabine (GEM) for 48 h at different doses. The cell viability was analyzed by CCK-8 assay, and normalized to cells without gemcitabine treatment. C. Expression levels of miRNAs in Bxpc-3 cells were analyzed by RT-qPCR analysis with the treatment of gemcitabine (2.5 μM) for 48 h. D, E. Expression levels of miR-145 in Bxpc-3 (D) and Panc-1 (E) cells treated with different doses of gemcitabine. Data from three independent experiments were shown as mean ± SEM. * indicated significant difference at P<0.05. ;** indicated significant difference at P<0.01.