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. 2016 Sep 27;7(43):70898–70911. doi: 10.18632/oncotarget.12286

Figure 5. GPR81 depletion blocks breast cancer growth and survival in xenograft tumors.

Figure 5

A. Tumor volumes of MCF7-shCTL (n=10) and MCF7-shGPR81 (n=10) xenografts were measured over a period of 50 days after cell inoculation. The data are expressed as the mean volume±SEM; **, P<0.05. B. Representative images of the xenograft tumors (top) and tumor weights (bottom) at 50 days after tumor cell injection. The data are expressed as the mean weight±SEM; **, P<0.05. C. Ki-67-positive cell numbers were determined in individual xenograft tumors. Representative IHC staining of the tumors from each group of mice is presented (left). The bars represent the mean percentage of Ki-67-positive cells±SEM; *, P<0.01 compared with MCF7-shCTL mice (right). D. Representative images of TUNEL staining in tumor tissues from xenografts (left). The bars represent the mean percentage of TUNEL-positive cells (apoptotic cells)±SEM; **, P<0.05 compared with MCF7-shCTL mice (right).