Table 5. Toxicities comparison between Arm A (standard chemoradiotherapy) and Arm B (standard chemoradiotherapy plus consolidation chemotherapy).
Toxicity/number of patients (%) | Arm Aa (N = 65) | Arm Bb (n = 71) | ||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Grade 0 | Grade 1 | Grade 2 | Grade 3 | Grade 4 | Grade 0 | Grade 1 | Grade 2 | Grade 3 | Grade 4 | |||||||||||
No. | % | No. | % | No. | % | No. | % | No. | % | No. | % | No. | % | No. | % | No. | % | No. | % | |
Gastrointestinal reaction | 8 | 12.3 | 10 | 15.4 | 41 | 63.1 | 2 | 3.1 | 4 | 6.1 | 0 | 0 | 20 | 28.2 | 43 | 60.6 | 2 | 2.8 | 6 | 8.4 |
Radiation enteritis | 39 | 60 | 16 | 24.6 | 10 | 15.4 | 0 | 0 | 0 | 0 | 20 | 28.2 | 43 | 60.6 | 8 | 11.2 | 0 | 0 | 0 | 0 |
Radiation cystitis | 45 | 69.2 | 4 | 6.2 | 16 | 24.6 | 0 | 0 | 0 | 0 | 39 | 54.9 | 20 | 28.2 | 12 | 16.9 | 0 | 0 | 0 | 0 |
Radioepidermitis | 30 | 46.2 | 27 | 41.5 | 8 | 12.3 | 0 | 0 | 0 | 0 | 24 | 33.8 | 41 | 57.7 | 6 | 8.5 | 0 | 0 | 0 | 0 |
Myelosuppression | 12 | 18.5 | 19 | 29.2 | 26 | 40 | 8 | 12.3 | 0 | 0 | 1 | 1.4 | 18 | 25.4 | 34 | 47.9 | 18 | 25.3 | 0 | 0 |
Arm A consisted of paclitaxel plus cisplatin chemotherapy combined with radiotherapy.
Arm B consisted of paclitaxel plus cisplatin chemoradiotherapy followed by paclitaxel plus cisplatin consolidation chemotherapy.