Table 2.

Monotherapy in the first-line setting

Trial name	Phase	Histology	Therapy	mPFS	6-month PFS	mORR	Ref
KEYNOTE-024	III	All	PEMBRO Q3W (PD-L1 >50%) vs PT-DC	10.3 months vs 6.0 months	62.1% vs 50.3%	44.8% vs 27.8%	14
				mOS	6-Month OS	DOR
			PEMBRO Q3W (PD-L1 >50%) vs PT-DC	NR vs NR	80.2% vs 72.4%	NR vs 6.3

Note: Completed trials in NSCLC.

Abbreviations: mPFS, median progression-free survival; PEMBRO, pembrolizumab; PD-L1, programmed death L1; PT-DC, platinum-doublet chemotherapy; mOS, median overall survival; NR, not reported; NSCLC, non-small-cell lung cancer; DOR, duration of response.