. 2017 Jan 23;38(3):301–311. doi: 10.1038/aps.2016.134

Table 1. PCSK9-targeting mechanisms.

Mechanisms	Representative agents	References
Blocking the combination of PCSK9 and LDLR	Mimetic Peptides	^25,35; ^57,58,59,60
	Adnectins	⁶¹
	Monoclonal antibodies (alirocumab; evolocumab; bococizumab)	^{62,63,64,65,66,67,68,69,70,71,72,73,74,75}
Inhibiting PCSK9 expression	CRISPR/Cas9 technology	¹¹; ^76,77,78,79
	Small molecules (berberine; oleanoic acid)	^{81,82,83,84,85,86,87,88,89,90,91}; ^{92,93,94,95,96,97,98,99}
	Antisense oligonucleotides	^100,101,102
	Small interfering RNAs	^103,104; ^58,59
Interfering PCSK9 secretion	Sortilin Sec24a	^105,106