Skip to main content
. 2016 Oct 21;7(46):74592–74601. doi: 10.18632/oncotarget.12816

Figure 3. Agonists of TLR7/8 and TLR9 are able to induce IFN-I secretion in SS patient cells.

Figure 3

A. PBMC from SS patients (n = 11, closed bar) and healthy controls (HC, n = 13, open bar) were cultured with medium (unstimulated, UNS) or stimulated for 48 h with agonists of TLR3, TLR7, TLR7/8 or TLR9. Supernatants were assessed for IFN-α secretion with a cytometric bead array. B. PBMC from SS patients (closed circle, n = 9) and HC (open circle, n = 12) were assessed for IFN-α, IFNR-I, IFN-λ and IFN-γ mRNA expression by qPCR. The results are presented as medians and IQRs.*p ≤ 0.05 compared with the HC group; #p ≤ 0.05, ##p ≤ 0.01 compared with the unstimulated culture.