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. 2016 Jul 24;7(46):74658–74677. doi: 10.18632/oncotarget.10813

Figure 4. The rescue effect of rapamycin on CSNPs-induced mitochondrial damage.

Figure 4

A. Mitochondrial structural disorganization in blastomeres was determined by TEM. B. The number and size of mitochondria per blastomere were determined by TEN and copy numbers of mitochondria per blastomere were determined by real time qRT-PCR in the control group, the CSNPs-treated group and the group treated with both CSNPs and rapamycin..C. Mitochondrial morphology in the control group, the CSNPs-treated group and the group treated with both rapamycin and CSNPs was visualized via MitoTracker Green FM staining in different groups of blastocysts. D. Mitochondrial activity levels of ATP synthase, ATP5b, Cbr1, Rhot2, Cytochrome C, Sco1, Sco2, Imp1, Mvp17, and Mrfp1 were evaluated using real time qRT-PCR. *, **, ***, NS, and ND indicate p < 0.05, p < 0.01, p < 0.001, not significant, and not determined, respectively. RM indicates rapamycin.