. 2016 Oct 5;7(46):74904–74916. doi: 10.18632/oncotarget.12484

Table 5. Prognostic value of the combination based on infiltrating density of CD57⁺ NK cells in tumor nest and in tumor stroma in Cox proportional hazards mode analysis (n = 138).

Clinical parameters	Univariate			Multivariate
Clinical parameters	HR	95% CI	P-value	HR	95% CI	P-value
Gender
Male/Female	0.982	0.682−1.536	0.937	1.046	0.645−1.698	0.854
Age (years)
≥ 60/< 60	0.930	0.627−1.378	0.717	0.795	0.522−1.213	0.288
Tumor size (cm)
≥ 3.5/< 3.5	1.417	0.941−2.132	0.095	1.332	0.852−2.082	0.209
TNM Stage
S_III/S_II	1.310	0.850−2.019	0.220	1.247	0.788−1.973	0.346
Treatment
Chemotherapy/None	1.132	0.610−2.098	0.695	0.939	0.486−1.812	0.851
Radiotherapy/ None	0.651	0.398−1.064	0.087	0.609	0.366−1.014	0.056
Both/None	0.658	0.091−4.743	0.678	0.800	0.103−6.227	0.831
NK cells in tumor nest and stroma
Nest high and Stroma low /Nest low and Stroma high	0.079	0.018−0.353	0.001	0.105	0.023−0.485	0.004
Both low /Nest low and Stroma high	0.160	0.037−0.687	0.014	0.211	0.047−0.954	0.043
Both high /Nest low and Stroma high	0.122	0.028−0.527	0.005	0.152	0.034−0.681	0.014

Values in bold signify P < 0.05.

Table 5. Prognostic value of the combination based on infiltrating density of CD57+ NK cells in tumor nest and in tumor stroma in Cox proportional hazards mode analysis (n = 138).