Table 6. Cox model analysis for the correlation between the infiltrating density of CD68⁺ macrophages in tumor nest and hazard ratio (n = 138).

Clinical parameters	Univariate			Multivariate
	HR	95% CI	P-value	HR	95% CI	P-value
Gender
Male/Female	0.982	0.682−1.536	0.937	0.912	0.574−1.449	0.697
Age (years)
≥ 60/< 60	0.930	0.627−1.378	0.717	0.842	0.559−1.269	0.412
Tumor size (cm)
≥ 3.5/< 3.5	1.417	0.941−2.132	0.095	1.466	0.944−2.277	0.089
TNM Stage
SIII/SII	1.310	0.850−2.019	0.220	1.170	0.744−1.839	0.497
Treatment
Chemotherapy/None	1.132	0.610−2.098	0.695	0.935	0.491−1.780	0.837
Radiotherapy/ None	0.651	0.398−1.064	0.087	0.599	0.363−0.987	0.044
Both/None	0.658	0.091−4.743	0.678	0.823	0.106−6.380	0.852
CD68+ macrophages in tumor nest
High/Low	1.541	1.038−2.289	0.032	1.488	0.996−2.221	0.052

Values in bold signify P < 0.05.