Figure 4. Changes in CD133+ AsPC1 xenograft mice after GV1001 and gemcitabine treatments.
A. AsPC1 cells were stained with isotype control (upper panel) or anti-CD133 antibody (lower panel), and CD133+ AsPC1 cells were examined by flow cytometry. CD133+ AsPC1 cells were sorted out, and isolated cells (1×106/mice) were inoculated to BALB/c nude mice. After xenograft tumors were firmly established, gemcitabine (125 mg/kg) was injected (i.p.) twice a week, and GV1001 (50 μg/mice) was injected (s.c.) daily for 2 weeks. B. Body weight and C. Tumor volume after GV1001 and gemcitabine treatments in CD133+ AsPC1 xenograft mice were followed twice a week, and represented as percent changes to initial average.