. 2016 Sep 16;7(46):75094–75103. doi: 10.18632/oncotarget.12058

Table 3. Univariate and multivariate analysis for the prognostic value of tumor deposits in regional lymph nodes negative rectal cancer with preoperative radiotherapy.

characteristics	Univariate analysis				Multivariate analysis
characteristics	No. (%)	HR	95% CI	P value	Adjusted HR	95% CI	P value
Sex		0.92	0.59 – 1.43	0.89
Male	1,962 (62.6)
Female	1,171 (37.4)
Age (yrs, median: 60)		1.69	1.09 – 2.62	0.01^a	1.70	0.98 – 2.98	0.06
≤ 60	1,615 (51.5)
> 60	1,518 (48.5)
Grade				0.04^a			0.15
Well differentiated	198 (7.1)	1	Reference		1	Reference
Moderately differentiated	2,303 (82.7)	0.73	0.33 – 1.60	0.43	0.77	0.23 – 2.52	0.66
Poorly differentiated or undifferentiated	285 (10.2)	1.45	0.59 – 3.60	0.42	1.51	0.41 – 5.61	0.54
ypT stage				< 0.001^a			0.21
Tis+T1	183 (5.8)	1	Reference		1	Reference
T2	433 (13.8)	1.36	0.43 – 4.33	0.61	1.77	0.21 – 14.73	0.60
T3	2,271 (72.5)	1.82	0.66 – 5.02	0.25	1.46	0.20 – 10.76	0.71
T4	246 (7.9)	6.13	2.08 – 18.01	0.001^a ^b	3.04	0.38 – 24.21	0.29
Distant metastasis		4.41	2.34 – 8.31	< 0.001^a	2.54	1.00 – 6.47	0.05
No	3,013 (96.2)
Yes	120 (3.8)
Marital status				0.01^a			0.60
Widowed	240 (7.7)	1	Reference		1	Reference
Married	1,871 (59.7)	0.47	0.25 – 0.88	0.01^a ^b	1.12	0.38 – 3.31	0.83
Others	1,022 (32.6)	0.63	0.33 – 1.20	0.16	1.47	0.49 – 4.42	0.50
CRM		1.95	1.07 – 3.56	0.01^a	2.00	1.12 – 3.56	0.02^a
Negative	1,434 (80.1)
Positive	357 (19.9)
Perineural Invasion		2.82	1.48 – 5.35	< 0.001^a	2.21	1.10 – 4.47	0.03^a
Negative	2,626 (93.1)
Positive	194 (6.9)
Tumor deposits		3.34	1.77 – 6.29	< 0.001^a	2.41	1.24 – 4.69	0.01^a
Absent	2,916 (93.1)
Present	217 (6.9)

^a:

Significant P value.

^b:

Significant P value after Bonferroni correction.

Abbreviation: CRM, circumferential resection margin. HR, hazard ratio, CI, confidence interval.