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. 2016 Oct 12;7(46):75118–75129. doi: 10.18632/oncotarget.12611

Figure 1. MiR-139-5p function is associated with MDR.

Figure 1

(A) The establishment of MDR cell lines. (B) The expression of miR-139-5p in two CRC drug-resistant cell lines. (C) The effect of miR-139-5p on the in vitro proliferation of both drug-resistant CRC cell lines, and the synergistic effect of miR-139-5p with anticancer drugs (***p < 0.001 miR-139-5p or drug-treated versus control, ###p < 0.001 miR-139-5p and drug co-treated versus control). (D) MiR-139-5p expression significantly enhanced the sensitivity of HCT-116 cells to VCR, L-OHP, 5-FU and Mit, and significantly reduced their IC50 values, based on the CCK-8 assay.