Skip to main content
. 2016 Oct 12;7(46):75118–75129. doi: 10.18632/oncotarget.12611

Figure 5. MiR-139-5p reverses CD44+/CD133+-associated MDR, partly by downregulating NOTCH1.

Figure 5

(A) The expression of NOTCH1 in drug-resistant and CD44+/CD133+ cells. (B) NOTCH1 siRNA significantly enhanced the sensitivity of drug-resistant and CD44+/CD133+ cells to VCR, L-OHP, 5-FU and Mit, and significantly reduced their IC50 values, based on a CCK-8 assay. (C) The percentage of CD44+ cells was reduced by overexpression of miR-139-5p or knockdown of NOTCH1. (D) The percentage of CD133+ cells was reduced by overexpression of miR-139-5p or knockdown of NOTCH1.