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. 2016 Oct 12;7(46):75118–75129. doi: 10.18632/oncotarget.12611

Figure 6. NOTCH1 restoration counteracts the inhibitory effects of miR-139-5p in CD44+/CD133+ cells.

Figure 6

(A) NOTCH1 restoration significantly increased the IC50 values reduced by miR-139-5p. (B) The percentage of CD44+ cells reduced by miR-139-5p was partly reversed by NOTCH1 restoration. (C) The percentage of CD133+ cells reduced by miR-139-5p was partly reversed by NOTCH1 restoration. (D) Tumors derived from HCT116 CD44+/CD133+ cells transfected with the vector, miR-139-5p or miR-139-5p plus NOTCH1 were implanted subcutaneously. The weights of the harvested tumors were measured.