Table 1. Clinical characteristics of all included patients at baseline.

Characteristic	Total (n = 2309)		ROS1 negative (n = 2262)		ROS1 positive (n = 47)		P value
	n	%	n	%	n	%
Age (years)
Median	61		64		57
Range	27–82		27–82		31–77
< 65	1486	64.4%	1452	64.2%	34	72.3%	0.248
≥ 65	823	35.6%	810	35.8%	13	27.7%
Sex
Male	894	38.7%	871	38.5%	23	48.9%	0.146
Female	1415	61.3%	1391	61.5%	24	51.1%
Smoking History
Never-smoker	1648	71.4%	1614	71.4%	34	72.3%	0.882
Former/current smoker	661	28.6%	648	28.6%	13	27.7%
Pathology Type
Adenocarcinoma	1811	78.4%	1774	78.4%	37	78.7%	0.961
Non-adenocarcinoma	498	21.6%	488	21.6%	10	21.3%
ECOG Performance Status
0–1	2055	89.0%	2011	88.9%	44	93.6%	0.431
≥ 2	254	11.0%	251	11.1%	3	6.4%

EGFR, epidermal growth factor receptorr; ECOG, Eastern Cooperative Oncology Group.