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. 2016 Sep 17;7(46):75185–75196. doi: 10.18632/oncotarget.12092

Figure 4. Smad3 was a direct target of miR-424-5p.

Figure 4

A. The potential miR-424-5p binding site at the 3'-UTR of Smad3 mRNA was computationally predicted by Tragetscan. B. Smad3 protein level in GC cells transfected with miR-424-5p inhibitor lentivirus and miR-424-5p mimics lentivirus. C. Luciferase activity was analyzed in cells co-transfcted with miR-424-5p mimics or negative control with pGL3-Smad3 or pGL3-Smad3-mut. D. A negative correlation between the expression levels of miR-424-5p and Smad3 in GC specimens (P<0.05).