Figure 2. PCA revealed ploidy-associated genes in c-Myc interactome of heart-liver A. and placenta B. Genes demonstrating the most pronounced variation with ploidy are indicated by enlarged symbols.

Symbol colours represent gene functions as listed in legend. In both, heart-liver (A) and in placenta (B) polyploidy is associated with the induction of developmental markers and genes related to protein synthesis, oxidative stress response and sugar metabolism. Genes related to aerobic respiration are mainly repressed. Purple lines mark 2SD and 3SD.