Table 1. Ploidy associated Myc interacting core gene list for human and mouse heart, liver and 4n/2n decidual cells shared by 3 data bases a,b.
| Upregulated | Downregulated | |
|---|---|---|
| in myc-associated polyploidy | in myc-associated polyploidy | |
| Cell Cycle | E2F8, CCNE1, CDKN2C, E2F5, CDK2, CCND3, LMNA, | CAV1, MYO5A, RB1, PAK2, RBL2, ARHGEF7 CDC42EP1, TBC1D4, |
| Growth and proliferation | BCAR1, EGFR, FGFR1, GNL3L, MYC, TK1, TLE1, MAP2K2, MCC, MTA1, HGF (MET), HRAS, NR2F2, RNH1, TAF6, TCF21, TGFA, IGFBP2, IGF1, WEE1, UBTF | RB1, PAK1; PAK2, RBL2 |
| Development | WNT9B, GATA2, WNT2B (MET), AXIN2, DVL1, KIT, SNAI1 (EMT), BMP2 (EMT), FGFR1 (MET), SNAI2 (EMT), BMP7 (EMT), | |
| Matrix, cytoskeleton, and focal adhesion | CTTN, SDC4, TUBG1, DSTN, FN1 (EMT), NCAM1, CDH2 (EMT), MMP14 (EMT), | MEF2A, DSP, CYTH1, PLEK, MCMBP |
| Glutamine metabolism | GLS2, GCDH, | |
| Protein degradation | PSMA7, PSMB5, PEX11a | |
| Ribosome | RRS1, NOLC1 | |
| Protein synthesis | GCAT, | |
| Sugar metabolism | PFKM, CA3, GNA11 | CA2 |
| Lipid metabolism | LDLR, PCBD1, SCD (EMT) | ALOX1 |
| Tumor supressors | LATS1, TP53 | RB1; PAK2; RBL2 |
| DNA repair | TP53BP2, BRCA1, H2AFX | |
| Oxidative stress | EPAS1 (HIF2A) (EMT), PEX11, PEX16; HP | HP |
| Chromatin | HDAC11 | |
| Signaling | NRIP1, TPST2, EXT1 | |
| Apoptosis | APAF1, BCL2L11, SYK, RB1, PAK, PAK2, RBL2 (p130) | |
| Immunity | LCK, IL7, CD5, TNFSF13B, CD8A, CD22, NFATC2, IFIT2, MAML3, ZFAND5, HP |
b
Gene functional categories have been chosen according to the GO classifications of the enrichment tools in String Data Base [1]. Genes may be present in more than one category.
(EMT) marks genes that were previously characterised as being induced or repressed, respectively, in epithelial-to-mesenchymal transition in the literature [34].
(MET) genes that were previously characterised as being induced or repressed, respectively at mesenchymal-to-epithelial transition in the literature [35]