Table 1. Peptide sequences selected from phage display peptide library screening on panitumumab.
Amino acid sequence of phage clone | Frequency | ||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Motif I | |||||||||||||||
V | P | G | W | S | Q | A | F | M | A | L | A | 21/50 (42%) | |||
N | H | V | P | Q | H | T | P | I | H | L | R | 2/50 (4%) | |||
A | H | V | P | Q | H | H | A | M | T | G | R | 2/50 (4%) | |||
V | P | G | W | S | Q | T | F | M | P | L | A | 1/50 (2%) | |||
G | H | V | T | Q | H | S | Q | R | G | Y | S | 1/50 (2%) | |||
G | H | V | P | Q | H | A | R | L | L | G | L | 1/50 (2%) | |||
T | H | V | P | E | H | L | L | K | P | R | P | 1/50 (2%) | |||
G | H | V | Q | Q | H | D | V | H | S | I | R | 1/50 (2%) | |||
Y | H | V | P | E | H | A | V | R | L | G | P | 1/50 (2%) | |||
K | H | V | L | Q | H | Q | T | S | M | T | M | 1/50 (2%) | |||
K | H | V | V | Q | H | E | Y | A | P | N | A | 1/50 (2%) | |||
H | H | T | D | E | H | W | L | F | A | K | K | 1/50 (2%) | |||
L | S | H | R | T | H | D | R | I | G | F | T | 1/50 (2%) | |||
Y | P | P | Q | E | R | T | V | H | K | Y | V | 1/50 (2%) | |||
Consensus motif I | H | V | P | G/Q | W/H | S | Q | ||||||||
Motif II | |||||||||||||||
D | T | D | W | V | R | M | R | D | S | A | R | 9/50 (18%) | |||
D | M | T | Y | M | E | R | R | D | S | A | R | 2/50 (4%) | |||
D | A | Y | T | Q | L | R | D | R | M | R | Q | 1/50 (2%) | |||
I | D | G | Y | P | G | S | P | R | L | P | W | 1/50 (2%) | |||
W | H | W | T | W | P | A | D | V | G | W | V | 1/50 (2%) | |||
Consensus motif II | D | T | X | X | X | X | X | R | D |