Figure 2. Suicide effect of F3.CE/CPT-11 system.

A. 1×10⁴ F3.CE cells were cultured with various concentration of CPT-11 at 37°C for 48 hr and the survival was determined. CPT-11 at concentration of 1 μM for 48 hrs killed >98% of F3.CE cells. B. BXPC3 human pancreatic cancer cells were incubated with 1 μM CPT-11 (3.75 mg/kg) for 48 hr with or without F3.CE cells. C., D. BXPC3 cancer cells co-incubated with or without F3.CE cells for 48 hr.