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. 2016 Sep 23;7(46):75366–75378. doi: 10.18632/oncotarget.12207

Figure 5. Diagrammatic model of EGFR pathway-modulated macrophage polarization in colon cancer.

Figure 5

IGF-1-induced IGF1R pathway activation might promote TAM polarization. EGFR inhibition in colon cancer cells altered the secreted cytokine profile. Secreted IGF-1 concentrations decreased when EGFR was inhibited in colon cancer cells, and IGF-1-induced TAM polarization was inhibited; experiments using the IGF1R inhibitor AG1024 and IGF-1 neutralizing antibody confirmed this effect. In conclusion, EGFR signaling pathway activity promoted IGF-1 secretion, which in turn induced TAM polarization.