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. 2016 Sep 23;7(46):75379–75393. doi: 10.18632/oncotarget.12211

Figure 7. Correlation of DNA repair gene methylation with the expression of a 6-gene IFNG signature (consisting of STAT1, HLA-DRA, IFNG, IDO1, CXCL9 and CXCL10) that has been identified as a predictive biomarker for PD-1 inhibitor efficacy in head and neck cancer.

Figure 7

Figure 7

A. Methylation of RAD51B and XRCC3 is correlated with the six-gene IFNG-signature expression in HNSCC. B. The ROC-area under the curve for the predictive value of XRCC3 binomial methylation (as defined by methylation > mean) is 0.77. C. The IFNG-signature shows a dose-dependent expression according to the number of hypermethylated candidate genes in HNSCC (methylation signature. A score of 1 indicates one candidate DNA repair gene with methylation > mean).