. 2016 Sep 26;7(46):75457–75467. doi: 10.18632/oncotarget.12255

Table 3. Stratified analyses between rs12922061, rs2290203, rs2981578, and rs10474352 and breast cancer risk.

Characteristics	rs12922061		P^b	P^c	rs2290203		P^b	P^c	rs2981578		P^b	P^c	rs10474352		P^b	P^c
Characteristics	OR(95%CI)	P^a	P^b	P^c	OR(95%CI)	P^a	P^b	P^c	OR(95%CI)	P^a	P^b	P^c	OR(95%CI)	P^a	P^b	P^c
Age (year)			0.231	0.223			0.252	0.227			0.036	0.046			0.734	0.730
≤40	1.073 (0.843, 1.366)	0.565			1.314 (1.059, 1.631)	0.013			0.705 (0.567, 0.877)	0.002			0.869 (0.700, 1.077)	0.199
>40	1.271 (1.094, 1.476)	0.002			1.124 (0.980, 1.288)	0.095			0.919 (0.802, 1.054)	0.229			0.908 (0.793, 1.039)	0.161
BMI			0.503	0.468			0.889	0.813			0.032	0.035			0.882	0.879
≤24	1.173 (1.008, 1.365)	0.039			1.185 (1.031, 1.362)	0.017			0.782 (0.682, 0.897)	4.5×10⁻⁴			0.889 (0.775, 1.021)	0.096
>24	1.295 (1.022, 1.640)	0.032			1.164 (0.945, 1.435)	0.153			1.066 (0.856, 1.327)	0.569			0.906 (0.737, 1.113)	0.347
Education level			0.477	0.468			0.362	0.307			0.622	0.592			0.844	0.846
Uneducated or primary school	1.137 (0.951, 1.360)	0.159			1.207 (1.024, 1.423)	0.025			0.855 (0.724, 1.009)	0.064			0.920 (0.783, 1.082)	0.316
High school or more	1.254 (1.029, 1.527)	0.025			1.078 (0.902, 1.288)	0.412			0.804 (0.673, 0.961)	0.016			0.898 (0.752, 1.073)	0.237
Age at menarche(year)			0.164	0.872			0.529	0.918			0.646	0.310			0.200	0.131
≤16	1.154 (1.000, 1.331)	0.049			1.161 (1.022, 1.318)	0.022			0.863 (0.759, 0.980)	0.023			0.860 (0.757, 0.977)	0.020
>16	1.477 (1.113, 1.960)	0.007			1.286 (0.975, 1.695)	0.075			0.804 (0.609, 1.062)	0.125			1.059 (0.813, 1.380)	0.669
Menopausal status			0.792	0.836			0.441	0.407			0.201	0.200			0.634	0.641
Premenopausal	1.189 (1.012, 1.396)	0.035			1.134 (0.984, 1.308)	0.083			0.806 (0.698, 0.931)	0.003			0.870 (0.755, 1.002)	0.054
Postmenopausal	1.233 (0.996, 1.527)	0.054			1.252 (1.025, 1.531)	0.028			0.951 (0.780, 1.159)	0.617			0.924 (0.758, 1.127)	0.436
Age at menopause (year)(postmenopausal women only)			0.978	0.969			0.759	0.751			0.387	0.380			0.296	0.310
<50	1.252 (0.859, 1.825)	0.242			1.179 (0.824, 1.688)	0.368			0.816 (0.572, 1.163)	0.260			1.127 (0.795, 1.598)	0.503
≥50	1.244 (0.975, 1.587)	0.079			1.261 (1.000, 1.589)	0.050			0.980 (0.780, 1.231)	0.862			0.887 (0.706, 1.113)	0.300
Years of menstruation(year)			0.065	0.062			0.977	0.995			0.107	0.116			0.464	0.469
<30	1.055 (0.871, 1.278)	0.857			1.175 (0.988, 1.397)	0.067			0.765 (0.643, 0.910)	0.003			0.852 (0.714, 1.016)	0.074
≥30	1.345 (1.134, 1.595)	0.001			1.171 (1.003, 1.368)	0.045			0.927 (0.793, 1.083)	0.339			0.929 (0.799, 1.079)	0.335
Age at first live birth (year)			0.857	0.655			0.327	0.746			0.180	0.159			0.455	0.653
≤25	1.205 (1.024, 1.418)	0.024			1.115 (0.959, 1.297)	0.156			0.801 (0.687, 0.933)	0.004			0.928 (0.800, 1.078)	0.329
>25	1.175 (0.942, 1.465)	0.152			1.264 (1.042, 1.532)	0.017			0.951 (0.787, 1.150)	0.606			0.847 (0.701, 1.023)	0.085
Parity			0.544	0.583			0.827	0.727			0.799	0.782			0.985	0.923
0-1	1.166 (0.969, 1.403)	0.104			1.173 (0.994, 1.384)	0.059			0.838 (0.709, 0.989)	0.037			0.894 (0.757, 1.056)	0.188
≥2	1.263 (1.056, 1.509)	0.010			1.204 (1.022, 1.420)	0.027			0.864 (0.733, 1.018)	0.081			0.892 (0.759, 1.047)	0.163
Breast feeding period (month)			0.373	0.323			0.894	0.881			0.082	0.129			0.531	0.502
<6	1.380 (1.025, 1.858)	0.034			1.152 (0.878, 1.513)	0.307			0.686 (0.515, 0.914)	0.010			0.971 (0.739, 1.276)	0.833
≥6	1.176 (1.021, 1.355)	0.025			1.176 (1.034, 1.337)	0.013			0.890 (0.784, 1.011)	0.073			0.878 (0.773, 0.996)	0.043
Family history of breast cancer			0.996	0.994			0.274	0.051			0.239	0.007			0.402	0.171
No	1.209 (1.063, 1.374)	0.004			1.155 (1.028, 1.298)	0.015			0.832 (0.740, 0.935)	0.002			0.888 (0.791, 0.996)	0.042
Yes	1.206 (0.500, 2.905)	0.677			2.926 (1.145, 7.479)	0.025			3.463 (1.204, 9.961)	0.021			1.687 (0.649, 4.383)	0.283

Adjusted for age, age at menarche and family history of breast cancer.

P for heterogeneity.

P for interaction. P≤0.000446.