. 2016 Oct 20;7(46):75518–75525. doi: 10.18632/oncotarget.12782

Table 2. Comparison of the allele frequencies of ERBB-family SNPs between the Irish HER2-Positive BC cohort and the 1000 Genomes UK and Chinese Han cohorts.

Gene	Protein Change	Accession number	HER2-IRE MAF n = 478	1kG-GBR MAF n = 182	1kG-CHB MAF n = 206	HER2 IRE vs 1kG GBR		HER2 IRE vs 1kG CHB
Gene	Protein Change	Accession number	HER2-IRE MAF n = 478	1kG-GBR MAF n = 182	1kG-CHB MAF n = 206	P-value	Adjusted P-value	P-value	Adjusted P-value
EGFR	N158N	rs2072454	0.416	0.54	0.44	0.014	0.04	0.566	0.57
	T584T	rs2227984	0.125	0.3	0.48	9.12x^e-06	4.56x^e-05	1.27x^e-16	1.91x^e-15
	H656H	rs10258429	0.088	0.07	0.05	0.591	0.81	0.135	0.17
	Q787Q	rs1050171	0.357	0.64	0.17	9.80x^e-09	7.35x^e-08	9.86x^e-06	2.11x^e-05
	T903T	rs1140475	0.125	0.11	0.05	0.760	0.88	0.007	0.01
	D994D	rs2293347	0.092	0.07	0.26	0.481	0.72	2.18x^e-06	5.45x^e-06
ERBB2	I655V	rs1136201	0.247	0.27	0.17	0.653	0.82	0.049	0.07
ERBB2	P1170A	rs1058808	0.275	0.65	0.52	2.34x^e-14	3.50x^e-13	2.02x^e-07	1.01x^e-06
ERBB3	I390I	rs2229046	0.09	0.04	0	0.034	0.08	1.40x^e-06	4.21x^e-06
ERBB3	R1116R	rs2271189	0.42	0.42	0.38	0.921	0.99	0.438	0.47

MAF = Mutant Allele Frequency; IRE = Ireland (n = 239); 1 kG GBR = 1000 Genomes Study participants from Great Britain (n = 91); 1kG CHB = 1000 Genomes Study participants from Beijing, China (n = 103).